Concentration-effect relationships for antihypertensive drugs

THE EFFECT OF ANTIHYPERTENSIVE DRUGS IN THE SUPPRESSION OF ATHEROSCLEROSIS

The present investigation was undertaken to evaluate the effect of antihypertensive drugs on aortic atherogenesis in hypercholesterolemic rabbits. In enalapril and nifedipine treated rabbits aortic atherosclerotic plaque involvement was significantly decreased (p<0. Oland p<O. 05, respectively) as compared to the control group. However, in hydrochlorothiazide treated rabbits aortic atheroge...

Concentration-effect analysis of antihypertensive drug responses.

It is now widely recognized that a rigid stepped-care approach to antihypertensive therapy is not universally appropriate. Individualized treatment may result in good or better blood pressure control and a simpler regimen without troublesome side effects. Successful development of such a strategy depends on accurate characterization of a dose-response relation and quantitative assessment of the...

Antihypertensive Drugs

Hypertension is one of the most serious concerns of modern medical practice. It is estimated that in the United States, as many as 60 million people are hypertensive or are being treated with antihypertensive drugs. Among the growing population of elderly Americans, some 15 million have high blood pressure. The level of blood pressure in itself is not a chief concern, since individuals with hig...

Antihypertensive drugs in pregnancy.

Nonadherence to antihypertensive drugs

BACKGROUND Hypertension drives the global burden of cardiovascular disease and its prevalence is estimated to increase by 30% by the year 2025. Nonadherence to chronic medication regimens is common; approximately 43% to 65.5% of patients who fail to adhere to prescribed regimens are hypertensive patients. Nonadherence to medications is a potential contributing factor to the occurrence of concom...